What Is Enhanced Liver Fibrosis. using The ELF™ test consists of three fully automated,
using The ELF™ test consists of three fully automated, two-site sandwich immunoassays using direct chemiluminometric technology. If detected in the early stages, liver disease progression can be prevented and much of the damage reversed. LifeLabs® offers the Fibrosis-4 (FIB-4) Index and Enhanced Liver Fibrosis (ELF™) Score to screen for liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Fibrosis itself causes no symptoms but can lead to portal hypertension (the scarring distorts blood flow through the liver) or cirrhosis (the scarring results in disruption of normal hepatic architecture and liver dysfunction). The Because of the increasing global burden of non-alcoholic fatty liver disease, lack of appropriate non-invasive testing options is a major concern. Fibrosis means scarring of the liver. 2 The Enhanced Liver Fibrosis (ELF™) blood test is a simple, accurate, non-invasive test that provides a simple, unitless numeric score that is generated via an algorithm for use in advanced liver fibrosis. 4 mg). Specific fibrosis markers in the blood can suggest the presence and severity of scarring. If the person is at low risk of advanced liver fibrosis, explain they are unlikely to have advanced liver fibrosis, and follow up the person in primary care. Background Clinicians use fibrosis in a liver biopsy to predict clinical outcomes of chronic liver disease. The performance of non-invasive tests has been evaluated against histological assessment of fibrosis but use of clinical outcomes as the reference standard would be ideal. 51 or above suggests advanced liver fibrosis. 9% of patients using semaglutide compared to 34. The enhanced liver fibrosis (ELF) test was derived and validated in a large cohort of patients and shown to have Jul 18, 2025 · The Enhanced Liver Fibrosis (ELF) score is a validated serum biomarker panel that measures three matrix turnover proteins to accurately assess liver fibrosis iver disease is a liver biopsy but this is invasive and expensive. 6 This is a newer The Enhanced Liver Fibrosis (ELFTM) Test is a noninvasive blood test that measures three direct markers of fibrosis. 3,4 Early recognition of progressive fibrosis and intervention is key for improved outcomes. The ELF Test is a non-invasive blood test that measures three direct markers of fibrosis: hyaluronic acid (HA), procollagen III amino-terminal peptide (PIIINP), and tissue inhibitor of matrix Quest Diagnostics offers the Liver Fibrosis, Fibrosis-4 (FIB-4) Index Panel (test code 30555), which includes tests for AST, ALT, and platelet count, plus calculation of the FIB-4 index. TGFβ1 was a key mediator of postoperative regeneration in fibrotic liver. 21 hours ago · The diagnostic workup for MASH requires a sequential approach starting with exclusion of other liver diseases, followed by confirmation of hepatic steatosis with cardiometabolic risk factors, and then fibrosis staging using noninvasive tests—with liver biopsy reserved for cases with discordant results or when definitive diagnosis is needed. This cross-sectional study investigates use of the noninvasive enhanced liver fibrosis test to estimate advanced fibrosis among patients with nonalcoholic fatty liver disease. Jan 8, 2026 · Enhanced Liver Fibrosis (ELF): a blood test measuring levels of hyaluronic acid, procollagen 3, amino terminal peptide, and matrix metalloproteinase 1 to provide a more detailed evaluation of the 2 days ago · 6. The Enhanced Liver Fibrosis (ELF) test is a non-invasive measure of liver fibrosis that requires a simple blood sample. 3% with placebo. It can be used to help diagnose and monitor non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatitis B and The 2022 American Association of Clinical Endocrinology (AACE) guidelines recommend specialized blood tests and imaging to determine risk of significant fibrosis. NAFLD comprises different stadia going Aug 4, 2025 · What this study adds This study demonstrates that the use of the enhanced liver fibrosis (ELF) test in primary care can facilitate the early diagnosis of liver damage among people with alcohol use disorder and reduce unnecessary referrals to specialist liver services. 4 days ago · Ultrasound can be enhanced with acoustic radiation force impulse (ARFI) elastography to simultaneously assess for liver fibrosis if chronic liver disease is suspected. Dec 2, 2018 · The enhanced liver fibrosis (ELF) test is a blood test that measures three molecules involved in liver matrix metabolism to give a score reflecting the severity of liver fibrosis. Though this test is not commercially available in the United States, ELF is typically used to assess the risk of progression Dec 17, 2024 · The enhanced liver fibrosis (ELF) test is a blood test that gives a score to reflect the severity of liver fibrosis. Find out more about fibrosis. Patients were assessed after 72 weeks. This makes identifying and quantifying the degree of fibrosis extremely important to risk-stratify patients and determine who needs further evaluation and treatment of liver disease. Fibrosis scoring systems (FIB-4 and ELF) This page includes information about the ELF and Fib-4 fibrosis scoring systems. We would like to show you a description here but the site won’t allow us. An easy, noninvasive way to assess risk of NASH disease progression 20% of patients with NAFLD progress to nonalcoholic steatohepatitis (NASH), which is strongly linked to liver fibrosis and can lead to cirrhosis, liver transplantation, or even death. Nov 28, 2023 · BOSTON — Treatment with aldafermin 3 mg appeared to be well-tolerated and significantly reduced Enhance Liver Fibrosis score after 48 weeks among patients with metabolic dysfunction 4 days ago · At the beginning of 2021, South West London Pathology (SWLP) will be introducing the Enhanced Liver Fibrosis (ELF™) Test from Siemens to our repertoire. 3 days ago · FDA granted breakthrough therapy designation to pemvidutide based on its potential in treating metabolic dysfunction–associated steatohepatitis (MASH). ELF measurements have proven valuable for identifying patients with NASH with advanced fibrosis (F3 or F4) at risk of progressing to cirrhosis and/or LREs. The test has the potential to identify people at high risk of advanced liver fibrosis earlier than the current standard of care. 1 A selection of the most widely used and validated non-invasive tests are compared below: Enhanced Liver Fibrosis (ELFTM) Test: A direct marker panel that combines hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinase 1 (TIMP-1) into a single score[4]. Mar 22, 2023 · Liver fibrosis occurs when the healthy tissue of your liver becomes scarred and cannot work as well. Enhanced liver fibrosis (ELF) assesses 3 blood-based fibrosis markers and is a well-validated measure of fibrosis. Feb 10, 2025 · The Enhanced Liver Fibrosis (ELF) score is a proprietary blood test that measures three elements involved in matrix turnover to assess liver fibrosis. Interestingly, AAV-shTGFβ1 accelerated the regeneration of fibrotic functional liver remnant and improved fibrosis, while LY2157299 only enhanced liver regeneration. Health Technology Wales looked for evidence on the ELF test for people considered at intermediate risk of advanced liver fibrosis. For people with MASLD, the National Institute for Health and Care Excellence (NICE) suggests offering testing for advanced liver fibrosis in prim ry care using the non-invasive enhanced liver fibrosis (ELF) test. Liver fibrosis versus the inflammatory process is recognized as the key driver of pathogenicity in NAFLD/ NASH. Enhanced Liver Fibrosis (ELF)™ Test measures Non-invasive serum panel assessing liver fibrosis. Aug 1, 2020 · The enhanced liver fibrosis test has been suggested as a non-invasive blood test to aid the diagnosis of severe liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Atellica® IM Enhanced Liver Fibrosis (ELF™) is for in vitro diagnostic use in the determination of an ELF score based on the combined quantitative measurements of hyaluronic acid, amino‑terminal propeptide of type III procollagen, and tissue inhibitor of matrix metalloproteinase 1 in human serum using the Atellica® IM AnalyzerAtellica IM ELF is indicated as a prognostic marker in Feb 11, 2025 · An elevated Enhanced Liver Fibrosis (ELF) test result indicates that a patient with fatty liver disease is at increased risk of progression to cirrhosis and Oct 30, 2023 · The liver is a powerhouse organ, performing a variety of tasks that are essential to maintaining good health. ELF measurements have proven valuable for assessing the likelihood of disease progression to cirrhosis and liver-related clinical events in patients with advanced fibrosis (F3 or F4) due to MASH. ”1 The Enhanced Liver Fibrosis (ELF) score is an ECM marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease. 5 days ago · Enhanced Cross-Sectional Imaging Multiphasic contrast-enhanced CT or MRI should be performed to better characterize liver morphology, evaluate for hepatocellular carcinoma, and assess vascular anatomy 1, 2 MRI is superior to CT for visualizing bands of fibrosis on both noncontrast and contrast-enhanced sequences 2 The efficacy of Resmetirom in liver fibrosis regression has been primarily demonstrated in the pivotal Phase 3 MAESTRO-NASH trial. Enhanced Liver Fibrosis (ELF) Panel What it measures: fibrosis Who should take it: diagnosed NAFLD/NASH patients Where to get it: Europe The Enhanced Liver Fibrosis (ELF) panel, is a blood test developed by Siemens Healthineers that measures fibrosis using serum markers. Expanded Reimbursement Access: The American Medical Association has published a Category 1 CPT code for the ELF Test on Atellica analyzers and ADVIA Centaur systems. Artificial Intelligence is also improving liver fibrosis assessment and fetal anomaly detection. The test can initially be requested by GPs in the borough of Wandsworth. Why do you need an ELF blood test? Apr 14, 2016 · Enhanced Liver Fibrosis (ELF) test is a novel blood test that measures levels of three direct markers [Hyaluronic Acid (HA), Amino-terminal Propeptide of Type III collagen (PIIINP) and Tissue Inhibitor of Matrix Metalloproteinase 1 (TIMP-1)] of fibrosis and utilizes an algorithm to generate a numeric score. Background and aims: The enhanced liver fibrosis (ELF) score is a blood test that combines three markers linked to liver fibrosis. It is a stage of long-term liver disease. The ELF test provides a non-invasive approach to evaluate liver health 3 days ago · FDA granted breakthrough therapy designation to pemvidutide based on its potential in treating metabolic dysfunction–associated steatohepatitis (MASH). Nov 17, 2022 · Enhanced Liver Fibrosis (ELF) score is an extracellular matrix (ECM) marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease Order Enhanced Liver Fibrosis (ELF) TestA simple blood test that can assess prognosis of patients with advanced fibrosis (F3 or F4) due to MASH*. During liver fibrogenesis, lysyl oxidase enzymes become upregulated, which facilitate ε amino groups of lysine in extracellular matrix p … The Enhanced Liver Fibrosis Test (ELF) is designed to identify signs of mild to moderate liver fibrosis before any significant damage occurs. Mar 22, 2023 · Liver fibrosis occurs when the healthy tissue of your liver becomes scarred and cannot work as well. Assess the risk of NAFLD/NASH progression and liver-related events with a simple blood test. Dec 3, 2025 · Liver fibrosis has the potential to advance to irreversible cirrhosis or hepatocellular carcinoma, rendering early diagnosis and intervention of utmost importance. The enhanced liver fibrosis (ELF) test is a blood-based biomarker panel used to assess liver fibrosis severity and predict liver-related outcomes. 30, the ELF score is performed. The enhanced liver fibrosis (ELF) test is a blood test that gives a score to reflect the severity of liver fibrosis. Feb 21, 2023 · LIVERFASt (Fibronostics) is a blood test for detecting and staging the fibrosis (scarring), activity (inflammation) and steatosis (fat build-up) of the liver. While weight loss and lifestyle modifications can help reverse disease, compliance can be a challenge. One of the most important predictors of liver related morbidity and mortality is stage of liver fibrosis. Specialized techniques like contrast-enhanced ultrasound aid in liver metastasis diagnosis, while intravascular ultrasound is crucial for coronary artery disease. It is indicated as a prognostic marker in conjunction with other laboratory findings and clinical assessments in patients with advanced fibrosis (F3 or F4) due to nonalcoholic Diagnosis and Management Approaches Diagnosing advanced liver fibrosis involves methods to assess liver scarring and its impact on function. The ELF test score, indicating the degree of fibrosis, is calculated from measurement of three markers of fibrosis; hyaluronic acid (HA), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and aminoterminal propeptide of Enhanced Liver Fibrosis (ELFTM) Test Understanding a person’s risk of progression to end-stage liver disease can lead to better patient management and significantly improved outcomes. NICE recommends diagnosing people as having advanced fibrosis if the E Jun 28, 2021 · The Enhanced Liver Fibrosis (ELF) test is a serological biomarker for fibrosis staging in chronic liver disease, however its utility in alcohol-related liver disease warrants further validation. Though this test is not commercially available in the United States, ELF is typically used to assess the risk of progression The enhanced liver fibrosis (ELF) test is a blood-based biomarker panel used to assess liver fibrosis severity and predict liver-related outcomes. The Enhanced Liver Fibrosis (ELF™) Test is a non-invasive blood test that measures three direct markers of fibrosis. 6 For patients in high-risk groups with an indeterminate or high fibrosis-4 (FIB-4) index, the Enhanced Liver Fibrosis Score, or ELFTM Score, is a recommended option. A liver with fibrosis can still do all its usual jobs. Enhanced Liver Fibrosis (ELF) test — a score of 10. Try these 11 foods for optimal liver health. Why do you need an ELF blood test? Jan 26, 2022 · The Enhanced Liver Fibrosis (ELF) Test from Siemens Healthineers is now available in the United States, providing broad clinical access to the minimally invasive prognostic tool. The utility of the ELF score has been demonstrated primarily in Western countries, but whether it is useful in areas The Enhanced Liver Fibrosis (ELF™) blood test is a simple, accurate, non-invasive test that provides a simple, unitless numeric score that is generated via an algorithm for use in advanced liver fibrosis. Nov 1, 2023 · The Enhanced Liver Fibrosis (ELF™) Test is an effective diagnostic tool used to measure the amount of fibrosis, or scarring, in the liver. 2 When CT with Contrast May Be Appropriate If CT imaging is necessary (when MRI is contraindicated or unavailable), specific technical requirements must be met: The Enhanced Liver Fibrosis (ELF) Test is a noninvasive blood test that quantifies three analytes which directly contribute to liver fibrosis. 1 Furthermore, 1 in 5 patients with advanced fibrosis progress to cirrhosis in 2. Apr 14, 2016 · Enhanced Liver Fibrosis (ELF) test is a novel blood test that measures levels of three direct markers [Hyaluronic Acid (HA), Amino-terminal Propeptide of Type III collagen (PIIINP) and Tissue Inhibitor of Matrix Metalloproteinase 1 (TIMP-1)] of fibrosis and utilizes an algorithm to generate a numeric score. Nov 17, 2022 · Enhanced Liver Fibrosis (ELF) score is an extracellular matrix (ECM) marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease Mar 24, 2021 · Results: Liver regeneration following ALPPS was lower in fibrotic rats than non-fibrotic rats. Twenty percent of patients with NAFLD progress to nonalcoholic steatohepatitis (NASH), which is strongly linked to liver fibrosis and can lead to cirrhosis, liver transplantation, or death. Apr 14, 2021 · An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver disease (NAFLD) worldwide. A simple blood test can help identify those at risk. The enhanced liver fibrosis test has been suggested as a non-invasive blood test to aid the diagnosis of severe liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). It includes three specific markers: hyaluronic acid (HA), tissue inhibitor of metalloproteinases 1 (TIMP-1), and aminoterminal propeptide of type III procollagen (PIIINP). Photoacoustic imaging combines light and sound for high-resolution cancer detection. com Introduction: Transient elastography (TE) noninvasively measures liver stiffness and indirectly evaluates fibrosis. Fibrosis is the first stage of liver scarring. The Enhanced Liver Fibrosis (ELF) score is an ECM marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease. Fibrosis of the Liver - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version. Liver benefits In the Phase 3 ESSENCE trial, patients with MASH and moderate to advanced fibrosis were given weekly semaglutide (2. If the FIB-4 index is ≥1. Our study results showed that the test has a high negative predictive value, especially in populations with low d … Dec 7, 2025 · Main Laboratory The Doctors Laboratory The Halo Building, 1 Mabledon Place London, WC1H 9AX, UK Tel: +44 (0)20 7307 7373 Email: tdl@tdlpathology. Includes hyaluronic acid, PIIINP, and TIMP-1. Resolution of steatohepatitis (inflammation and liver cell damage) was seen in about 62. The NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score estimates amount of scarring in the liver based on several laboratory tests. This can help them plan your care and treatment. 7–10 ELF is included as a Enhanced Liver Fibrosis (ELF) Panel What it measures: fibrosis Who should take it: diagnosed NAFLD/NASH patients Where to get it: Europe The Enhanced Liver Fibrosis (ELF) panel, is a blood test developed by Siemens Healthineers that measures fibrosis using serum markers. 5 years. The efficacy of Resmetirom in liver fibrosis regression has been primarily demonstrated in the pivotal Phase 3 MAESTRO-NASH trial. 7–10 ELF is included as a It is used for detecting and staging liver fibrosis, activity and steatosis in people with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatitis B and hepatitis C. This article reviews the evidence supporting ELF as a diagnostic test, a prognostic marker and its use in disease monitoring. The Enhanced Liver Fibrosis (ELFTM) Test is a noninvasive blood test that quantifies three analytes which directly contribute to liver fibrosis. The ELF test is a non-invasive blood test which combines three direct serum biomarkers of liver fibrosis. But if the damage continues it can cause cirrhosis. 5 days ago · A panel of 11 Japanese hepatology experts conducted a modified Delphi process to evaluate consensus recommendations regarding the use of noninvasive tests (NITs), including the fibrosis-4 index, enhanced liver fibrosis test, Mac-2-binding protein glycosylation isomer, type IV collagen 7S, cytokeratin-18 fragments, and imaging modalities such as Current noninvasive methods for assessing liver fibrosis and steatosis are reviewed, finding the Fibrosis-4 index, Enhanced Liver Fibrosis test, and elastography have gained the strongest clinical footholds for the diagnosis of advanced fibrosis. Liver fibrosis has the potential to advance to irreversible cirrhosis or hepatocellular carcinoma Feb 21, 2023 · LIVERFASt (Fibronostics) is a blood test for detecting and staging the fibrosis (scarring), activity (inflammation) and steatosis (fat build-up) of the liver. Clinical Significance Enhanced Liver Fibrosis (ELF) Score - The Enhanced Liver Fibrosis (ELF) score predicts progression to cirrhosis and liver-related events in patients with advanced fibrosis due to NASH. The trial evaluated two primary endpoints at 52 weeks: 1) NASH resolution with no worsening of fibrosis, and 2) Fibrosis improvement by at least one stage with no worsening of the NAFLD Activity Score (NAS). Dec 3, 2025 · GPPN achieves targeted delivery to activated hepatic stellate cells via hydrazine-mediated covalent binding to LysAld, which is enriched in fibrotic regions of the liver, and improves magnetic resonance imaging signals of liver fibrosis to enable more accurate assessment of disease progression. Sep 22, 2023 · The Enhanced Liver Fibrosis (ELF) test is indicated “as a prognostic marker in conjunction with other laboratory findings and clinical assessments in patients with advanced fibrosis (F3 or F4) due to nonalcoholic steatohepatitis (NASH), to assess the likelihood of progression to cirrhosis and liver-related clinical events. These non-invasive blood tests help identify high-risk patients and reduce the need for complex procedures, ensuring early and effective management of liver health. Direct assessment of fibrosis has proven valuable for identifying patients at risk of progressing to cirrhosis and/or LREs. Diagnosis is based on blood tests, imaging techniques, and sometimes liver biopsy. 5 days ago · Enhanced Cross-Sectional Imaging Multiphasic contrast-enhanced CT or MRI should be performed to better characterize liver morphology, evaluate for hepatocellular carcinoma, and assess vascular anatomy 1, 2 MRI is superior to CT for visualizing bands of fibrosis on both noncontrast and contrast-enhanced sequences 2 Jan 7, 2026 · Collectively, our results demonstrate the utility of hiPSC derivatives for modeling liver diseases and reveal how heterotypic interactions can drive disease progression. Some fibrosis can be reversible. Direct assessment of fibrosis has proven valuable for identifying patients at risk of progressing to cirrhosis and/or liver-related events. It can be used to help diagnose and monitor non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatitis B and We would like to show you a description here but the site won’t allow us. Enhanced Liver Fibrosis (ELF) blood test: A simple guide for patients An ELF blood test helps your doctor understand the health of your liver by checking for signs of scarring and damage. Nov 8, 2025 · Wondering how do you calculate your ELF score? This guide explains the lab-based process for the Enhanced Liver Fibrosis test, detailing what it measures and how doctors interpret the results to assess liver health and prognosis. The Fibrosis-4 (FIB-4) Index for Liver Fibrosis is a non-invasive scoring system based on several laboratory tests that help to estimate the amount of scarring in the liver. The innovative aspects are that LIVERFASt may simplify diagnosing and monitoring liver disease and damage. The Enhanced Liver Fibrosis (ELF) Score is a noninvasive test that indicates whether a patient with NASH and advanced fibrosis has a higher or lower risk of disease progression to cirrhosis (for those with F3 fibrosis) or other liver-related clinical events (for those with F3 or F4 fibrosis) within 1 to 4 years. Nov 17, 2022 · Enhanced Liver Fibrosis (ELF) score is an extracellular matrix (ECM) marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease. FIB-4 Index Panel with Reflex to Enhanced Liver Fibrosis (ELF) Score - This reflex provides a cost-effective, medically justified, and guideline supported approach to evaluating a patient at risk of NAFLD with liver fibrosis. Blood tests, including liver function tests, provide information about liver health, inflammation, or damage. The ELF test score, indicating the degree of fibrosis, is calculated from measurement of three markers of fibrosis; hyaluronic acid (HA), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and aminoterminal propeptide of Aug 1, 2013 · The Enhanced Liver Fibrosis (ELF) score is an ECM marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease.